Cyclopropylamine
(Redirected from Cyclopropyl amine)
| Names | |
|---|---|
| Other names
aminocyclopropane, CPA
| |
| Identifiers | |
3D model (JSmol)
|
|
| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value).Lua error in Module:EditAtWikidata at line 29: attempt to index field 'wikibase' (a nil value). |
| EC Number |
|
| E number | Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value). |
| KEGG | |
PubChem CID
|
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C3H7N | |
| Molar mass | 57.096 g·mol−1 |
| Appearance | colorless liquid |
| Melting point | −35.4 °C (−31.7 °F; 237.8 K) |
| Boiling point | 49–50 °C (120–122 °F; 322–323 K) |
| Hazards | |
| GHS labelling:[1] | |
| GHS02: FlammableGHS05: CorrosiveGHS07: Exclamation mark | |
| Warning | |
| H225, H302, H314, H317, H332, H412 | |
| P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P362+P364, P363, P370+P378, P403+P235, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Cyclopropylamine is the organic compound with the formula C3H5NH2. It is a simple amine derivative of cyclopropane.[1] As a precursor to pesticides and pharmaceuticals, it is produced on a multi-ton scale from the carboxamide.[2] Cycloproylamine is first member of the aminocycloalkanes, which includes cyclobutylamine, cyclopentylamine, and cyclohexylamine.
Cyclopropylamines
[edit | edit source]Many aminocyclopropanes are known, most prominently the amino acid aminocyclopropane-1-carboxylic acid.
The cyclopropylamine group is featured in several pharmaceutical drugs:[2]
- Simeprevir, used to treat hepatitis C infections
- Risdiplam, used to treat spinal muscular atrophy
- ciprofloxacin, an antibiotic.
Cyclopropylamines can be prepared by the Kulinkovich reaction, by dialkylation of bromonitromethane, and various cyclopropanations.[3][4]
References
[edit | edit source]- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ a b Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).
- ^ Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).