Copper naproxen

Copper naproxen

File:Copper naproxen.jpg Sample of copper naproxen in a glass vial
File:Copper naproxen.svg
Names
Other names Copper(II) 6-methoxy-a-methyl-2-naphthaleneacetate
Identifiers
3D model (JSmol)	Interactive image
ECHA InfoCard
E number
CompTox Dashboard (EPA)	{{#property:P3117}}
InChI InChI=1S/2C14H14O3.Cu/c2*1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h2*3-9H,1-2H3,(H,15,16);/q;;+2/p-2/t2*9-;/m00./s1 Key: GBARQYVMLWJLEP-NAWJVIAPSA-L
SMILES COc1cc2ccc(cc2cc1)[C@H](C)C(=O)[O-].COc1cc2ccc(cc2cc1)[C@H](C)C(=O)[O-].[Cu+2]
Properties
Chemical formula	C28H26CuO6
Molar mass	522.056 g·mol−1
Appearance	Green solid
Solubility	Soluble in methanol, 1,4-dioxane, DMSO, DMF
Related compounds
Related compounds	Copper aspirinate Copper ibuprofenate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Copper naproxen is a chemical complex of copper²⁺ chelated with the anti-inflammatory drug naproxen. Copper complexes of NSAIDs like naproxen have been shown to have greater anti-inflammatory properties than the base drug.

Copper naproxen can be found as a monohydrate, and it can form complexes with other organic molecules such as nicotinyl alcohol, 3-methylpyridine, and caffeine.

Preparation

Copper naproxen is prepared by reacting sodium naproxen with a copper(II) salt such as copper(II) sulfate.

2 C₁₄H₁₃NaO₃ + CuSO₄ → C₂₈H₂₆CuO₆ + Na₂SO₄