Glycoprotein hormones, alpha polypeptide

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Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene.[1]

Thyroid-stimulating hormone (TSH) and the gonadotropin hormones human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein hormones are identical; however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.[2] CGA levels are regulated by ELAVL1/HuR, and the small molecule Eltrombopag, which targets HuR/RNA interactions, has been shown to reduce CGA levels in human cultured cells.[3]

References

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Further reading

[edit | edit source]
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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