S100A6
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). S100 calcium-binding protein A6 (S100A6) is a protein that in humans is encoded by the S100A6 gene.[1]
Function
[edit | edit source]The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.[1]
Interactions
[edit | edit source]S100A6 has been shown to interact with S100B[2][3] and SUGT1.[4]
Pathology
[edit | edit source]S100A6 to be reported as possible diagnostic marker of papillary thyroid carcinoma.[5]
References
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Further reading
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