p120 catenin

Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). p120 catenin, or simply p120, also called catenin delta-1, is a protein that in humans is encoded by the CTNND1 gene.^[1]

Function

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined.^[2]

Clinical significance

File:Chromogenic immunohistochemistry for p120 in invasive lobular carcinoma.jpg

Immunohistochemistry for p120 has cytoplasmic staining in invasive lobular carcinoma (shown), but has membranous staining in invasive ductal carcinoma, thereby helping to distinguish these cancer types.

Either loss or cytoplasmic localization of p120 is a common feature in the progression of several types of carcinoma.^[3]

Interactions

CTNND1 has been shown to interact with:

β-Catenin,^[4]^[5]
CDH1,^[4]^[6]^[7]^[8]^[9]^[10]^[11]^[12]
CDH2,^[13]^[14]
Collagen, type XVII, alpha 1,^[15]
Cortactin,^[16]
FYN,^[6]^[16]
MUC1,^[17]
Nephrin,^[18]
PSEN1,^[19]
PTPN6,^[20]
PTPRJ,^[21]
PTPRM,^[22]
VE-cadherin,^[23]^[24]
YES1,^[6] and
ZBTB33^[25]

References

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External links

Human CTNND1 genome location and CTNND1 gene details page in the UCSC Genome Browser.

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p120 catenin

Contents

Function

Clinical significance

Interactions

See also

References

Further reading

External links

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p120 catenin

Function

Clinical significance

Interactions

See also

References

Further reading

External links

Navigation menu

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