Protein chibby homolog 1
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.[1][2][3]
Function
[edit | edit source]Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.[3]
Interactions
[edit | edit source]CBY1 has been shown to interact with Beta-catenin.[4] CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.[5]
References
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External links
[edit | edit source]- Human CBY1 genome location and CBY1 gene details page in the UCSC Genome Browser.
Further reading
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