Lysidine (chemical)
(Redirected from C4H8N2)
| Names | |
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| Preferred IUPAC name
2-Methyl-4,5-dihydro-1H-imidazole | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C4H8N2 | |
| Molar mass | 84.12 g/mol |
| Melting point | 87 °C (189 °F; 360 K) (decomposes) |
| Hazards | |
| GHS labelling:[2] | |
| GHS07: Exclamation mark | |
| Warning | |
| H315, H319, H335 | |
| P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501 | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Lysidine is a derivative of 2-imidazoline. It is a colorless solid with basic properties and soluble in organic solvents. It is used as a precursor to other compounds of pharmaceutical interest.
Synthesis and reactions
[edit | edit source]It is prepared by condensing ethylenediamine with acetic acid to give the diamide, which undergoes CaO-induced cyclization. Lysidine is an intermediate in the synthesis of the drug metronidazole. In the presence of Raney nickel, it undergoes dehydrogenation to 2-methylimidazole, which can then be further elaborated.[3]
File:Synthesis of metronidazole.png
References
[edit | edit source]- ^ Lysidine at Sigma-Aldrich
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