Aficamten

Aficamten
Clinical data
Other names	CK-274
Identifiers
	IUPAC name N-[(1R)-5-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methylpyrazole-4-carboxamide;
CAS Number	2364554-48-1;
PubChem CID	139331495;
ChemSpider	114935503;
UNII	B1I77MH6K1;
ChEMBL	ChEMBL4847050;
E number	{{#property:P628}}
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Chemical and physical data
Formula	C18H19N5O2
Molar mass	337.383 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC1=NC(=NO1)C2=CC3=C(C=C2)[C@@H](CC3)NC(=O)C4=CN(N=C4)C;
	InChI InChI=1S/C18H19N5O2/c1-3-16-21-17(22-25-16)12-4-6-14-11(8-12)5-7-15(14)20-18(24)13-9-19-23(2)10-13/h4,6,8-10,15H,3,5,7H2,1-2H3,(H,20,24)/t15-/m1/s1; Key:IOVAZWDIRCRMTM-OAHLLOKOSA-N;

Aficamten (CK-274) is a cardiac myosin inhibitor^[1] developed by Cytokinetics for the treatment of obstructive hypertrophic cardiomyopathy.^[2]^[3]^[4]

References

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