Acylfulvene

Acylfulvene
Names
	Preferred IUPAC name (6′R)-6′-Hydroxy-2′,4′,6′-trimethylspiro[cyclopropane-1,5′-inden]-7′(6′H)-one
Identifiers
CAS Number	125392-76-9 ;
3D model (JSmol)	Interactive image; Interactive image;
ChEMBL	ChEMBL121987 ;
ChemSpider	324633 ;
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E number	Lua error in Module:Wikidata at line 880: attempt to index field 'wikibase' (a nil value).
PubChem CID	365701;
UNII	G4T2FA57Q6 ;
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	InChI InChI=1S/C14H16O2/c1-8-6-10-9(2)14(4-5-14)13(3,16)12(15)11(10)7-8/h6-7,16H,4-5H2,1-3H3/t13-/m0/s1 Key: HLAKJNQXUARACO-ZDUSSCGKSA-N ; InChI=1/C14H16O2/c1-8-6-10-9(2)14(4-5-14)13(3,16)12(15)11(10)7-8/h6-7,16H,4-5H2,1-3H3/t13-/m0/s1 Key: HLAKJNQXUARACO-ZDUSSCGKBE;
	SMILES CC1=CC2=C(C3(CC3)C(C(=O)C2=C1)(C)O)C; O=C1C/3=C/C(=CC\3=C(/C2([C@]1(O)C)CC2)C)C;
Properties
Chemical formula	C14H16O2
Molar mass	216.28 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Acylfulvene is a class of cytotoxic semi-synthetic derivatives of illudin, a natural product that can be extracted from the jack o'lantern mushroom (Omphalotus olearius).^[1] One important acylfulvene, 6-hydroxymethylacylfulvene (irofulven), has been evaluated for the treatment of a wide assortment of cancers and tumors.^[2] It is thought that acylfulvene compounds kill cancer cells by DNA alkylation (see DNA methylation).^[3]

References

^ Anchel, M.; Hervey, A.; Robbins, W. J. Proc. Natl. Acad. Sci. U.S.A. 1950, 36, 300
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^ Woynarowski, Jan M.; Napier, Cheryl; Koester, Steven K.; Chen, Shih-Fong; Troyer, Dean; Chapman, William; Macdonald, John R. Biochemical Pharmacology (1997), 54 (11), 1181-1193 CODEN: BCPCA6; Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).. (Elsevier Science Inc.)

[1] Anchel, M.; Hervey, A.; Robbins, W. J. Proc. Natl. Acad. Sci. U.S.A. 1950, 36, 300

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[3] Woynarowski, Jan M.; Napier, Cheryl; Koester, Steven K.; Chen, Shih-Fong; Troyer, Dean; Chapman, William; Macdonald, John R. Biochemical Pharmacology (1997), 54 (11), 1181-1193 CODEN: BCPCA6; Lua error in Module:Citation/CS1/Configuration at line 2172: attempt to index field '?' (a nil value).. (Elsevier Science Inc.)

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Acylfulvene

References

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