Alpha granule
| Alpha granule | |
|---|---|
| File:Platelet structure.png Alpha granules shown in a platelet | |
| Details | |
| Part of | Platelets |
| Identifiers | |
| Latin | granulum alpha |
| TA98 | Lua error in Module:Wikidata at line 746: attempt to index field 'wikibase' (a nil value). |
| TH | {{#property:P1694}} |
| TE | {{#property:P1693}} |
| FMA | {{#property:P1402}} |
| Anatomical terminology [[[d:Lua error in Module:Wikidata at line 865: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]] | |
Alpha granules, (α-granules) also known as platelet alpha-granules are a cellular component of platelets. Platelets contain different types of granules that perform different functions, and include alpha granules, dense granules, and lysosomes.[1] Of these, alpha granules are the most common,[1] making up 50% to 80% of the secretory granules.[2] Alpha granules contain several growth factors.[3]
Contents
[edit | edit source]Contents include insulin-like growth factor 1, platelet-derived growth factors, TGF beta, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V,[4] and von Willebrand factor).[5]
The alpha granules express the adhesion molecule P-selectin[6] and CD63.[7] These are transferred to the membrane after synthesis.
The other type of granules within platelets are called dense granules.
Clinical significance
[edit | edit source]A deficiency of alpha granules is known as gray platelet syndrome.
See also
[edit | edit source]References
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