α-Mannosidase
(Redirected from Alpha-mannosidase)
| α-Mannosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| File:5jm0.jpg α-Mannosidase 1, tetramer, Saccharomyces cerevisiae | |||||||||
| Identifiers | |||||||||
| EC no. | 3.2.1.24 | ||||||||
| CAS no. | 9025-42-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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α-Mannosidase (EC 3.2.1.24, α-D-mannosidase, p-nitrophenyl-α-mannosidase, α-D-mannopyranosidase, 1,2-α-mannosidase, 1,2-α-D-mannosidase, exo-α-mannosidase) is an enzyme involved in the cleavage of the α form of mannose. Its systematic name is α-D-mannoside mannohydrolase.[3][4]
Isoenzymes
[edit | edit source]Humans express the following three α-mannosidase isoenzymes:
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Applications
[edit | edit source]It can be utilized in experiments that determine the effects of the presence or absence of mannose on specific molecules, such as recombinant proteins that are used in vaccine development.[5]
Pathology
[edit | edit source]A deficiency can lead to α-mannosidosis.[6]
References
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External links
[edit | edit source]- GeneReviews/NCBI/NIH/UW entry on Alpha-Mannosidosis
- OMIM entries on Alpha-Mannosidosis
- alpha-Mannosidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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