Renin receptor
Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[1][2][3]
Function
[edit | edit source]The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[4]
This protein is associated with proton-translocating ATPases which have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3]
References
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Further reading
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External links
[edit | edit source]- ATP6AP2 human gene location in the UCSC Genome Browser.
- ATP6AP2 human gene details in the UCSC Genome Browser.
