Alpha-actinin-1

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

Function

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha-actinin-1 is an F-actin cross-linking protein – a bundling protein that is thought to anchor actin to a number of intracellular structures. Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.

Interactions

Alpha-actinin-1 has been shown to interact with:

• CDK5R1,
• CDK5R2,
• Collagen, type XVII, alpha 1,
• GIPC1,
• PDLIM1,
• Protein kinase N1,
• SSX2IP, and
• Zyxin.
• PTPRT (PTPrho)

See also

• Actinin

External links

• Actinin, alpha 1 Info with links in the Cell Migration Gateway
• Human ACTN1 genome location and ACTN1 gene details page in the UCSC Genome Browser.