Isoflavonoid synthase

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Isoflavonoid synthase
Identifiers
EC no.1.14.13.136
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

2-hydroxyisoflavanone synthase (EC 1.14.13.136, CYT93C, IFS, isoflavonoid synthase) is an enzyme with systematic name liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration).[1][2][3] This enzyme catalyses the following chemical reactions:

liquiritigenin + O2 + NADPH + H+ 2,4',7-trihydroxyisoflavanone + H2O + NADP+

and

(2S)-naringenin + O2 + NADPH + H+ 2,4',5,7-tetrahydroxyisoflavanone + H2O + NADP+

Isoflavonoid synthase requires cytochrome P450.

References

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